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1994-09-24
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Document 0533
DOCN M9490533
TI Angiogenic process in bacillary angiomatosis.
DT 9411
AU Kostianovsky M; Greco MA; Department of Pathology and Cell Biology,
Thomas Jefferson; University, Philadelphia, Pennsylvania.
SO Ultrastruct Pathol. 1994 May-Jun;18(3):349-55. Unique Identifier :
AIDSLINE MED/94345812
AB Eight cases of cutaneous bacillary angiomatosis related to acquired
immunodeficiency syndrome were studied by light and electron microscopy
and by immunohistochemistry with a panel of antibodies specific for
endothelial and histiocytic markers. Light microscopy showed an
inflammatory reaction with florid neovascularization and clusters of
Warthin-Starry-positive bacilli. In addition, solid areas of spindle
cells were also present that in some cases mimicked Kaposi's sarcoma or
other sarcomas. The investigation focused primarily on the spindle cell
areas and the angiogenic process present in bacillary angiomatosis. By
immunohistochemistry the lesions, including the spindle cell areas,
expressed all endothelial markers used; CD34, factor VIII-related
antigen, and Ulex europaeus 1 were the most consistent in intensity,
however. In those areas the other endothelial markers, BNH9 and
Psophocarpus tetragonolobus, were weak and not always uniform. The
macrophage/monocyte markers used were alpha 1-antitrypsin, lysosome, kp1
(CD68), and polyclonal factor XIIIa; these revealed a sprinkle of
positive cells ranging from 10% to 20% of the cell population. By
electron microscopy primitive capillaries were present lined by plump
endothelial cells containing frequent abluminal microprocesses forming
intercellular lumina. Mitoses and intracytoplasmic lumen formation were
infrequent. The study illustrates that bacillary angiomatosis is
composed of active endothelial neoformation with the spindle cells
representing immature endothelial cells. Furthermore, the features of
this angiogenic process recapitulate the morphologic events described in
experimental models.
DE Angiomatosis, Bacillary/MICROBIOLOGY/*PATHOLOGY
Capillaries/ULTRASTRUCTURE Human HIV Infections/COMPLICATIONS
Immunoenzyme Techniques Male Neovascularization/*MICROBIOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).